Grenades are of limited use against any but the weakest enemies. Even in earlier versions, before enemies were made more powerful, if I'm walking along the Barbados canyon and see a bunch of bandits hiding behind a rock, I stop before I get close enough to trigger them to charge, lob a grenade, it does a little damage to them, then they charge and my party wipes them out because we have good swords and armour. Damage from a direct hit from a grenade, let alone from just being in the blast radius, is minimal compared to a decent swipe from one of the better swords.
So if you're relying on grenades to deal with new improved enemies, you're going to be in a lot of trouble...
So if you're relying on grenades to deal with new improved enemies, you're going to be in a lot of trouble...