Perhaps you are having the same problme some of us had. Try this fix from NathanKell and Sirus_Darke:
Sirus_Darke:
<!--quoteo--><div class='quotetop'>QUOTE</div><div class='quotemain'><!--quotec-->Go into the PROGRAMCONTROLS folder and open up init_pc.c in Notepad or similar editing tool.
Find the following lines
<!--c1--><div class='codetop'>CODE</div><div class='codemain'><!--ec1-->--------------------------------------------------------------------------------
CI_CreateAndSetControls( "General", "DCH_Quicksave", CI_GetKeyCode("VK_F5"), 0, false );
CI_CreateAndSetControls( "General", "DCH_Quickload", CI_GetKeyCode("VK_F9"), 0, false );
--------------------------------------------------------------------------------<!--c2--></div><!--ec2--><!--QuoteEnd--></div><!--QuoteEEnd-->
NathanKell:
<!--quoteo--><div class='quotetop'>QUOTE</div><div class='quotemain'><!--quotec-->Anyway, my idea is this: try...change[ing] Time Accel at the top to something else and then set quicksave to VK_MULTIPLY and quickload to VK_DIVIDE (this is what Deus Ex used I believe, and it's what I've used ever since in games with QS/QL because it's near the mouse).
But make sure you _also_ delete these lines further down in the file:
<!--c1--><div class='codetop'>CODE</div><div class='codemain'><!--ec1-->--------------------------------------------------------------------------------
// dchaley -->
// need these for quick save
objControlsState.key_codes.VK_F5 = 116;
objControlsState.key_codes.VK_F5.img = "a"; // changed by KAM
objControlsState.key_codes.VK_F9 = 120;
objControlsState.key_codes.VK_F9.img = "f"; // changed by KAM
// dchaley <--
--------------------------------------------------------------------------------<!--c2--></div><!--ec2--><!--QuoteEnd--></div><!--QuoteEEnd-->
For more information visit this thread. <a href="http://forum.piratesahoy.net/`ftopic3297-0`-`asc-80`.php" target="_blank">http://forum.piratesahoy.net/`ftopic32...asc-80`.php</a>
Page 7 has the above fix.
Hope this works.